3,6-Cyclopropylene-Δ4-tetrahydrophthalic Anhydride

• CAT Number: C000607
• CAS Number: 944-41-2
• Molecular Formula: C₁₁H₁₀O₃
• Molecular Weight: 190.2
• Purity: ≥95%
• Synonyms: rel-(3aR,4R,4aR,5aS,6S,6aS)-3a,4,4a,5,5a,6-Hexahydro-4,6-etheno-1H-cycloprop[f]isobenzofuran-1,3(3aH)-dione; Tricyclo[3.2.2.02,4]non-8-ene-6,7-dicarboxylic Anhydride Stereoisomer; (3aα,4β,4aα,5aα,6β,6aα)-4,4a,5,5a,6,6a-Hexahydro-4,6-etheno-1H-cycloprop[f]isobenzofuran-1,3(3aH)-dione
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: -20°C

3,6-Cyclopropylene-Δ4-tetrahydrophthalic Anhydride (CAT: C000607) plays a pivotal role as an intermediate in the synthesis of Tecovirimat, a notable antipoxvirus compound. Tecovirimat demonstrates potent antiviral activity against various orthopoxviruses, including vaccinia, monkeypox, camelpox, cowpox, ectromelia (mousepox), and variola viruses. Through its mechanism of action, Tecovirimat inhibits extracellular virus formation, providing a valuable defense against these viral infections. The synthesis of Tecovirimat involves the strategic utilization of 3,6-Cyclopropylene-Δ4-tetrahydrophthalic Anhydride to introduce crucial structural elements, contributing to the compound’s efficacy and potential clinical significance in managing orthopoxvirus-related diseases.

Reference

Yang, Guang., et al.: J. Virol., 79, 13139 (2005);