3CAI

• CAT Number: I002986
• CAS Number: 28755-03-5
• Molecular Formula: C10H8ClNO
• Molecular Weight: 193.63
• Purity: ≥95%
• Target: Akt
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 2-chloro-1-(1H-indol-3-yl)ethanone
• InChI: InChI=1S/C10H8ClNO/c11-5-10(13)8-6-12-9-4-2-1-3-7(8)9/h1-4,6,12H,5H2
• InChIKey: LLZQFAXTCYDVTR-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)C(=O)CCl

3CAI（Cat No.:I002986） is a potent and specific inhibitor of AKT, a key kinase involved in various cellular processes including cell survival, proliferation, and metabolism. As an allosteric inhibitor, 3CAI binds to a distinct site on AKT, disrupting its activation and downstream signaling. This inhibition of AKT activity leads to the suppression of cell growth and proliferation. In preclinical studies, 3CAI has demonstrated efficacy both in vitro and in vivo, making it a promising candidate for further development as an anti-cancer therapeutic agent targeting the AKT pathway.

 

Reference

[1]. Kim DJ, et al. (3-Chloroacetyl)-indole, a novel allosteric AKT inhibitor, suppresses colon cancer growth in vitro and in vivo. Cancer Prev Res (Phila). 2011 Nov;4(11):1842-51.