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1640971-60-3-(3R,4R)-3-[(6-Amino-4-pyrimidinyl)methylamino]-4-methyl-b-oxo-1-piperidinepropanenitrile (3R,4R)-3-[(6-Amino-4-pyrimidinyl)methylamino]-4-methyl-b-oxo-1-piperidinepropanenitrile

(3R,4R)-3-[(6-Amino-4-pyrimidinyl)methylamino]-4-methyl-b-oxo-1-piperidinepropanenitrile

For research use only. Not for therapeutic Use.

  • CAT Number: C000028
  • CAS Number: 1640971-60-3
  • Molecular Formula: C₁₄H₂₀N₆O
  • Molecular Weight: 288.35
  • Purity: ≥95%
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Related Small Molecules: (6-(Trifluoromethyl)pyridin-2-yl)methanamine hydrochloride     Pyrazolo[1,5-a]pyridine-6-carbaldehyde     4-Chloro-4′-fluoro-3-nitrobenzophenone    

(3R,4R)-3-[(6-Amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-piperidinepropanenitrile (CAT: C000028) serves as a valuable reagent in the context of structural activity relationship (SAR) studies focused on Tofacitinib bioisosteres. Tofacitinib is a known Janus kinase (JAK) inhibitor utilized for treating autoimmune disorders. This derivative plays a crucial role in probing the impact of structural modifications on the biological activity of compounds analogous to Tofacitinib.


Catalog Number C000028
CAS Number 1640971-60-3
Molecular Formula C₁₄H₂₀N₆O
Purity ≥95%
Solubility Chloroform (Slightly, Sonicated), Methanol (Slightly)
Appearance White to Off-White Solid
Storage -20°C, Inert atmosphere
Reference

Gehringer, M., et al.: ChemMedChem, 9, 2516 (2014)

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