(3R,5R,6S)-Atogepant

• CAT Number: I042853
• Molecular Formula: C29H23F6N5O3
• Molecular Weight: 603.52
• Purity: ≥95%
• Synonyms: (3S)-N-[(3R,5R,6S)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6′-5,7-dihydrocyclopenta[b]pyridine]-3′-carboxamide
• IUPAC Name: (3S)-N-[(3R,5R,6S)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1H-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide
• InChI: InChI=1S/C29H23F6N5O3/c1-13-16(22-18(30)4-5-19(31)23(22)32)8-20(26(42)40(13)12-29(33,34)35)38-25(41)15-7-14-9-28(10-21(14)37-11-15)17-3-2-6-36-24(17)39-27(28)43/h2-7,11,13,16,20H,8-10,12H2,1H3,(H,38,41)(H,36,39,43)/t13-,16-,20+,28-/m0/s1
• InChIKey: QIVUCLWGARAQIO-FFIZURTESA-N
• SMILES: C[C@H]1[C@H](C[C@H](C(=O)N1CC(F)(F)F)NC(=O)C2=CC3=C(C[C@@]4(C3)C5=C(NC4=O)N=CC=C5)N=C2)C6=C(C=CC(=C6F)F)F

(3R,5R,6S)-Atogepant（Cat No.:I042853）is a selective, small-molecule CGRP (calcitonin gene-related peptide) receptor antagonist used in the treatment of chronic migraine. It is a stereoisomer of atogepant, with a specific configuration at the 3R, 5R, and 6S positions, contributing to its high affinity and selectivity for the CGRP receptor. By blocking the action of CGRP, a neuropeptide involved in migraine pathophysiology, (3R,5R,6S)-atogepant helps reduce the frequency and severity of migraines. This compound represents a promising therapeutic approach for individuals with chronic migraines who do not respond well to traditional treatments.