(3S,4S,3’S)-Ezetimibe

• CAT Number: C000660
• CAS Number: 1593543-07-7
• Molecular Formula: C₂₄H₂₁F₂NO₃
• Molecular Weight: 409.43
• Purity: ≥95%
• Synonyms: (3S,4S)-1-(4-Fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: -20°C
• IUPAC Name: (3S,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one
• InChI: InChI=1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22-,23+/m0/s1
• InChIKey: OLNTVTPDXPETLC-RJGXRXQPSA-N
• SMILES: C1=CC(=CC=C1C2C(C(=O)N2C3=CC=C(C=C3)F)CCC(C4=CC=C(C=C4)F)O)O

(3S,4S,3’S)-Ezetimibe (Cat No.:C000660) is an enantiomerically pure form of Ezetimibe, a medication used to lower cholesterol levels by inhibiting the absorption of dietary cholesterol from the intestines. This specific enantiomer has a distinct three-dimensional arrangement of its constituent atoms. Ezetimibe works by blocking the Niemann-Pick C1-like 1 protein, reducing cholesterol absorption and leading to lower blood cholesterol levels. Research on (3S,4S,3’S)-Ezetimibe may focus on its pharmacological properties, interactions with cellular pathways and its potential benefits in managing hypercholesterolemia and reducing the risk of cardiovascular disease.

Reference

van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)