4α-Phorbol 12,13-didecanoate

• CAT Number: R066775
• CAS Number: 27536-56-7
• Molecular Formula: C40H64O8
• Molecular Weight: 672.9
• Purity: ≥95%
• Synonyms: 4α-PDD;4α-Phorbol 12,13-dicaprinate
• Storage: -20°C
• InChI: InChI=1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/
• InChIKey: DGOSGFYDFDYMCW-OEFRVDPMSA-N
• SMILES: CC(C1=O)=C[C@]2([H])[C@@]1(O)CC(CO)=C[C@]3([H])[C@]2(O)[C@H](C)[C@@H](OC(CCCCCCCCC)=O)[C@]4(OC(CCCCCCCCC)=O)[C@H]3C4(C)C

4α-Phorbol 12,13-didecanoate is a negative control for phorbol esters, phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) and phorbol 12,13-didecanoate (PDD). Though inactive for signaling through PKC, 4α-phorbol 12,13-didecanoate has been shown to activate transient receptor potential vanilloid 4 (TRPV4) channels.

Reference

1.Watanabe, H.,Davis, J.B.,Smart, D., et al. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J. Biol. Chem. 277(16), 13569-13577 (2002).