4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide

• CAT Number: C000606
• CAS Number: 1289942-55-7
• Molecular Formula: C₂₀H₁₈F₄N₄O₂
• Molecular Weight: 422.38
• Purity: ≥95%
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: 4°C, Inert atmosphere

4-[[2-[[4-Cyano-3-(trifluoromethyl)phenyl]amino]-1,1-dimethyl-2-oxoethyl]amino]-2-fluoro-N-methyl-benzamide(CAT: C000606) is an impurity of Enzalutamide , an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex.

Reference

Scher, H. I., et al.: Lancet, 375, 1437 (2010); Bellmunt, J., et al.: Ther. Adv. Med. Oncol., 2, 189 (2010); Ryan, C. J., et al.: J. Clin. Oncol., 29, 3651 (2011);