4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one

• CAT Number: C000609
• CAS Number: 1460272-53-0
• Molecular Formula: C₂₄H₂₃FN₄O₄
• Molecular Weight: 450.46
• Purity: ≥95%
• Synonyms: Olaparib Metabolite M15
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Appearance: White to Off-White Solid
• Storage: -20°C, Inert atmosphere

4-((3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorophenyl)(hydroxy)methyl)phthalazin-1(2H)-one(CAT: C000609) is an impurity associated with Olaparib. Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, known for its role in cancer treatment. It has demonstrated efficacy in inducing significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Furthermore, recent studies have shown that Olaparib enhances the radiosensitivity of lung tumor xenografts, suggesting its potential use in combination with radiotherapy.

Reference

Weston, V.J. et al.: Blood, 116, 4578 (2010); Senra, J.M. et al.: Mol. Cancer Therap., 10, 1949 (2011); Schaefer, N.G. et al.: Nuc. Med. Comm., 32, 1046 (2011);