4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone

• CAT Number: C000094
• CAS Number: 1252018-10-2
• Molecular Formula: C₁₃H₁₇ClN₂O₃
• Molecular Weight: 284.74
• Purity: ≥95%
• Synonyms: (R)-4-[4-[(3-Chloro-2-hydroxypropyl)amino]phenyl]morpholin-3-one; Rivaroxaban Impurity E
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Storage: -20°C

4-[4-[[(2R)-3-Chloro-2-hydroxypropyl]amino]phenyl]-3-morpholinone(CAT: C000094), also known as Rivaroxaban Impurity E, is a specific impurity associated with Rivaroxaban. Rivaroxaban is an antithrombotic agent and a direct Factor Xa (FXa) inhibitor used to prevent and treat blood clots. The presence of impurities like Rivaroxaban Impurity E in pharmaceutical preparations is closely monitored and controlled, as these impurities can affect the safety and efficacy of the medication.

Reference

Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),