4-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl Butyric Acid

• CAT Number: C000041
• CAS Number: 2197414-57-4
• Molecular Formula: C₁₃H₁₄N₃O₄
• Molecular Weight: 277.28
• Purity: ≥95%
• Synonyms: 2-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)pentanedioic acid
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: Off-White to Pale Beige Solid
• Storage: 4°C, Inert atmosphere

4-(4-Amino-1-oxoisoindolin-2-yl)-4-carbamoyl butyric acid(CAT: C000041) is an open-chain impurity associated with lenalidomide, a medication used in the treatment of multiple myeloma and myelodysplastic syndromes. In pharmaceutical chemistry, understanding and characterizing impurities like this compound is crucial for ensuring the quality and safety of the final drug product. Impurities can arise during the synthesis and manufacturing processes, and their identification and control are essential to meet regulatory standards and ensure the efficacy and safety of lenalidomide in clinical use

Reference

Bartlett, J.B., et al.: Nature Rev., 4, 314 (2004), Mitsiades, C.S., et al.: Curr. Opin. Invest. Drugs, 5, 635 (2004), List, A., et al.: N. Engl. J. Med., 352, 549 (2005),