4-AMINO-1,8-NAPHTHALIMIDE

• CAT Number: M121602
• CAS Number: 1742-95-6
• Molecular Formula: C12H8N2O2
• Molecular Weight: 212.208
• Purity: ≥95%
• Synonyms: 4-Aminonaphthalimide;4-ANI
• Target: Epigenetics
• Storage: -20°C
• IUPAC Name: 6-aminobenzo[de]isoquinoline-1,3-dione
• InChI: InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16)
• InChIKey: SSMIFVHARFVINF-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. 4-amino-1,8-Naphthalimide (4-ANI) is an inhibitor of PARP (IC50 = 180 nM). It blocks radiation-induced PARP in cancer cells, potentiating the cytotoxicity of γ-radiation, although it is not cytotoxic in the absence of radiation. 4-ANI is used to study the role of PARP activity in various cell systems.