4-AMINO-5-CYANO-7-(BETA-D-RIBOFURANOSYL)PYRROLO[2,3-D]PYRIMIDINE

• CAT Number: M005696
• CAS Number: 606-58-6
• Molecular Formula: C12H13N5O4
• Molecular Weight: 291.26
• Purity: ≥95%
• Synonyms: NSC 63701;NSC 99843;TOYOCAMYCIN;3-d)pyrimidine-5-carbonitrile,4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(;4-amino-5-cyano-7-(d-ribofuranosyl)-7h-pyrrolo(2,3-d)pyrimidine;4-amino-7-beta-d-ribofuranosyl-7h-pyrrolo(2,3-d)pyrimidine-5-carbonitrile;a-399-y
• Target: Antibiotic
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at +4C
• IUPAC Name: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
• InChI: InChI=1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
• InChIKey: XOKJUSAYZUAMGJ-WOUKDFQISA-N
• SMILES: C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CN=C2N)C#N

4-Amino-5-cyano-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine（Cat No.:M005696）is a synthetic nucleoside analog used in biochemical research, particularly in studies involving nucleic acid metabolism and enzyme interactions. This compound mimics naturally occurring nucleosides and is often employed to investigate mechanisms of DNA and RNA synthesis, repair, and regulation. Its unique structure enables it to interact with enzymes like polymerases and kinases, providing insights into nucleotide processing pathways. Due to its versatility, this compound serves as a valuable tool in drug development and cancer research, particularly in understanding nucleoside analog-based therapies.

Reference

Toyocamycin, a new anti-candida antibiotic. Nishimura H. et al. J. Antibiot. 1956, 9A, 60.

Nucleoside antibiotics. Suhadolnik R. J. Wily-Interscience. 1970, 298.