For research use only. Not for therapeutic Use.
4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].
4-CMTB is both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids. 4-CMTB modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2)[1][2].
| Catalog Number | I010996 |
| CAS Number | 300851-67-6 |
| Synonyms | 2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide |
| Molecular Formula | C14H15ClN2OS |
| Purity | ≥95% |
| InChI | InChI=1S/C14H15ClN2OS/c1-9(2)12(10-3-5-11(15)6-4-10)13(18)17-14-16-7-8-19-14/h3-9,12H,1-2H3,(H,16,17,18) |
| InChIKey | AZYDQCGCBQYFSE-UHFFFAOYSA-N |
| SMILES | CC(C)C(C1=CC=C(C=C1)Cl)C(=O)NC2=NC=CS2 |
| Reference | [1]. Smith NJ, et al. Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011;80(1):163-173. [2]. Milligan G, Stoddart LA, Smith NJ. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br J Pharmacol. 2009;158(1):146-153. |
