For research use only. Not for therapeutic Use.
4-CPPC is the first reversible and selective small molecule inhibitor of the pro-inflammatory protein macrophage migration inhibitory factor-2 (a.k.a. MIF-2 or D-DT).
| Catalog Number | I020924 |
| CAS Number | 29553-70-6 |
| Synonyms | 4CPPC; 4 CPPC; 4-CPPC |
| Molecular Formula | C14H9NO6 |
| Purity | 98% |
| Target | Macrophage migration inhibitory factor (MIF) |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 4-(3-Carboxyphenyl)-2,5-pyridinedicarboxylic acid |
| InChI | InChI=1S/C14H9NO6/c16-12(17)8-3-1-2-7(4-8)9-5-11(14(20)21)15-6-10(9)13(18)19/h1-6H,(H,16,17)(H,18,19)(H,20,21) |
| InChIKey | NBVHLJGGHJLTGM-UHFFFAOYSA-N |
| SMILES | O=C(C1=NC=C(C(O)=O)C(C2=CC=CC(C(O)=O)=C2)=C1)O |
| Reference | 1: Pantouris G, Bucala R, Lolis EJ. Structural Plasticity in the C-Terminal Region of Macrophage Migration Inhibitory Factor-2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor. Biochemistry. 2018 Jul 3;57(26):3599-3605. doi: 10.1021/acs.biochem.8b00344. Epub 2018 Jun 12. PubMed PMID: 29847104; PubMed Central PMCID: PMC6123015. |
