4'-Hydroxy-2,4-dimethoxychalcone

• CAT Number: R065894
• CAS Number: 151135-64-7
• Molecular Formula: C17H16O4
• Molecular Weight: 284.31
• Purity: ≥95%
• Synonyms: (E)-3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C17H16O4/c1-20-15-9-5-13(17(11-15)21-2)6-10-16(19)12-3-7-14(18)8-4-12/h3-11,18H,1-2H3/b10-6+
• InChIKey: LNEYYODFMSUKGY-UXBLZVDNSA-N
• SMILES: COC1=CC(=C(C=C1)C=CC(=O)C2=CC=C(C=C2)O)OC

4′-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4′-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].
4′-Hydroxy-2,4-dimethoxychalcone (compound 2) is against P. falciparum D6 (IC50=4.2 μM) and W2 (IC50=4.8 μM)[1].
4′-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T1/2 of 1.94 hours, a Cmax of 158 ng/mL and an AUC of 384 ng•h/mL in four- to five-week-old ICR mice[1].

Reference

[1]. Clare E Gutteridge, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104.
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[2]. Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171.