4-hydroxy-3-Methoxyphenylglycol (piperazine salt)

• CAT Number: R066626
• CAS Number: 67423-45-4
• Molecular Formula: C22H34N2O8
• Molecular Weight: 454.52
• Purity: ≥95%
• Synonyms: MHPG piperazine;MOPEG piperazine
• Storage: -20°C
• IUPAC Name: 1-(4-hydroxy-3-methoxyphenyl)ethane-1,2-diol;piperazine
• InChI: InChI=1S/2C9H12O4.C4H10N2/c2*1-13-9-4-6(8(12)5-10)2-3-7(9)11;1-2-6-4-3-5-1/h2*2-4,8,10-12H,5H2,1H3;5-6H,1-4H2
• InChIKey: KCECBJRHWSOTMR-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)C(CO)O)O.COC1=C(C=CC(=C1)C(CO)O)O.C1CNCCN1

4-hydroxy-3-Methoxyphenylglycol (piperazine salt) is a metabolite of norepinephrine derived in part by deamination of normetanephrine or by O-methylation of dihydroxyphenylglycol after cellular uptake of either intermediate. It is released into the blood and cerebrospinal fluid and has been used as a biochemical index of recent sympathetic nervous system activity.

Reference

1.Kopin, I.J.,Axelrod, J. and Gordon, E. The metabolic fate of H3-epinephrine and C14-metanephrine in the rat. The Journal of Biological Chemisty 236, 2109-2136 (1961).