4-Hydroxy Atorvastatin-d5 calcium

• CAT Number: S000395
• CAS Number: 265989-45-5
• Molecular Formula: C33H28D5CaFN2O6
• Molecular Weight: 617.73
• Purity: ≥95%
• IUPAC Name: calcium;(3R,5R)-7-[2-(4-fluorophenyl)-4-[(4-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoate
• InChI: InChI=1S/2C33H35FN2O6.Ca/c2*1-20(2)31-30(33(42)35-24-12-14-25(37)15-13-24)29(21-6-4-3-5-7-21)32(22-8-10-23(34)11-9-22)36(31)17-16-26(38)18-27(39)19-28(40)41;/h2*3-15,20,26-27,37-39H,16-19H2,1-2H3,(H,35,42)(H,40,41);/q;;+2/p-2/t2*26-,27-;/m11./s1/i2*3D,4D,5D,6D,7D
• InChIKey: PYIWEMFVBXVPDU-UOXTVLSDSA-L
• SMILES: CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)O.CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=C(C=C4)O.[Ca+2]

4-Hydroxy Atorvastatin-d5 calcium（Cat No.:S000395） is a deuterated version of 4-hydroxy atorvastatin, where five hydrogen atoms are replaced with deuterium. This modification enhances its metabolic stability, facilitating detailed pharmacokinetic and metabolic studies. 4-Hydroxy atorvastatin is an active metabolite of atorvastatin, a widely used statin for lowering cholesterol and preventing cardiovascular disease. It inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis. The calcium salt form improves the compound’s solubility and bioavailability. The deuterated version helps researchers understand how atorvastatin is metabolized and its interactions within the body more accurately.