4’-Hydroxy Diclofenac

• CAT Number: R005072
• CAS Number: 64118-84-9
• Molecular Formula: C14H11Cl2NO3
• Molecular Weight: 312.146
• Purity: ≥95%
• Synonyms: 2-[(2,6-Dichloro-4-hydroxyphenyl)amino]benzeneacetic Acid; 4’-Hydroxydiclofenac
• Target: Drug Metabolite
• Storage: -20°C
• IUPAC Name: 2-[2-(2,6-dichloro-4-hydroxyanilino)phenyl]acetic acid
• InChI: InChI=1S/C14H11Cl2NO3/c15-10-6-9(18)7-11(16)14(10)17-12-4-2-1-3-8(12)5-13(19)20/h1-4,6-7,17-18H,5H2,(H,19,20)
• InChIKey: KGVXVPRLBMWZLG-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=C(C=C2Cl)O)Cl

4′-Hydroxy diclofenac is a major metabolite of diclofenac, a widely used nonsteroidal anti-inflammatory drug (NSAID). This metabolite is formed in the liver through the action of cytochrome P450 enzymes, particularly CYP2C9. Like diclofenac, 4′-hydroxy diclofenac retains some anti-inflammatory and analgesic activity, though it is generally less potent than the parent compound. The study of 4′-hydroxy diclofenac is important in understanding the pharmacokinetics, metabolism, and potential side effects of diclofenac, as well as in assessing its overall efficacy and safety profile in therapeutic use.