4’-Hydroxy-PhIP

• CAT Number: R011644
• CAS Number: 126861-72-1
• Molecular Formula: C13H12N4O
• Molecular Weight: 240.266
• Purity: ≥95%
• Synonyms: 4-(2-Amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol; 2-Amino-4’-hydroxy-1-methyl-6-phenylimidazo[4,5-b]pyridine
• Storage: Store at -20°C
• IUPAC Name: 4-(2-amino-1-methylimidazo[4,5-b]pyridin-6-yl)phenol
• InChI: InChI=1S/C13H12N4O/c1-17-11-6-9(7-15-12(11)16-13(17)14)8-2-4-10(18)5-3-8/h2-7,18H,1H3,(H2,14,15,16)
• InChIKey: UGJXOCBVCWTJFP-UHFFFAOYSA-N
• SMILES: CN1C2=C(N=CC(=C2)C3=CC=C(C=C3)O)N=C1N

4’-Hydroxy-PhIP (CAT: R011644) is a metabolite and derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a heterocyclic aromatic amine found in cooked meat and a known environmental carcinogen. The formation of this hydroxylated derivative occurs through enzymatic metabolism, primarily involving cytochrome P450 enzymes. In terms of pharmacological action, 4’-Hydroxy-PhIP is recognized for its potential role in contributing to the genotoxicity and carcinogenicity associated with PhIP exposure.