4-Hydroxyacetophenone oxime

• CAT Number: R048529
• CAS Number: 34523-34-7
• Molecular Formula: C8H9NO2
• Molecular Weight: 151.16
• Purity: ≥95%
• Synonyms: 4-[(E)-N-hydroxy-C-methylcarbonimidoyl]phenol
• InChI: InChI=1S/C8H9NO2/c1-6(9-11)7-2-4-8(10)5-3-7/h2-5,10-11H,1H3/b9-6+
• InChIKey: BVZSQTRWIYKUSF-RMKNXTFCSA-N
• SMILES: CC(=NO)C1=CC=C(C=C1)O

4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol). Acetaminophen is a potent cyclooxygenase-2 (COX-2) and hepatic N-acetyltransferase 2 (NAT2) inhibitor, and used antipyretic and analgesic agent[1][2].

Reference

[1]. Hinz, B, et al. Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J, 2008. 22(2): p. 383-90.
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[2]. Rothen JP, et al. Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo. Pharmacogenetics. 1998 Dec;8(6):553-9.
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