4-Hydroxyantipyrine

• CAT Number: R029322
• CAS Number: 1672-63-5
• Molecular Formula: C11H12N2O2
• Molecular Weight: 204.23
• Purity: ≥95%
• Synonyms: 4-hydroxy-1,5-dimethyl-2-phenylpyrazol-3-one
• InChI: InChI=1S/C11H12N2O2/c1-8-10(14)11(15)13(12(8)2)9-6-4-3-5-7-9/h3-7,14H,1-2H3
• InChIKey: SKVPTPMWXJSBTF-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N(N1C)C2=CC=CC=C2)O

4-Hydroxyantipyrine (4-Hydroxyphenazone; NSC 174055) is the major metabolite of Antipyrine (HY-B0171), can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Citicoline and Antipyrine in the brain[1][2].
4-Hydroxyantipyrine increase the tissue-to-plasma concentration ratio of Citicoline in the brain and liver and that of thiopental sodium in the brain, liver, and heart[1].
4-Hydroxyantipyrine enhances the blood-brain barrier (BBB) permeability of Antipyrine considering to be concerned with the increase of the Kp value of Antipyrine in the brain[2].

Reference

[1]. Ohkawa Y, et al. Effects of 4-hydroxyantipyrine and its 4-O-sulfate on antipyrine as biodistribution promoter. Biol Pharm Bull. 2001 May;24(5):529-34.
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[2]. Ohkawa Y, et al. Application of 4-hydroxyantipyrine and acetaminophen O-sulfate as biodistribution promoter. Biol Pharm Bull. 2001 Dec;24(12):1404-10.
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