For research use only. Not for therapeutic Use.
4-Hydroxyatomoxetine is an active metabolite of Atomoxetine. 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine hydrochloride is a potent and selective noradrenalin re-uptake inhibitor (Ki values are 5 nM, 77 nM and 1451 nM for inhibition of radioligand binding to human NET, SERT and DAT respectively)[1][2].
| Catalog Number | R006026 |
| CAS Number | 435293-66-6 |
| Synonyms | 3-methyl-4-[(1R)-3-(methylamino)-1-phenylpropoxy]phenol |
| Molecular Formula | C17H21NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H21NO2/c1-13-12-15(19)8-9-16(13)20-17(10-11-18-2)14-6-4-3-5-7-14/h3-9,12,17-19H,10-11H2,1-2H3/t17-/m1/s1 |
| InChIKey | PPXQPRLGNSJNJM-QGZVFWFLSA-N |
| SMILES | CC1=C(C=CC(=C1)O)OC(CCNC)C2=CC=CC=C2 |
| Reference | [1]. JT Brown, Single Dose Pharmacokinetics of Atomoxetine in Children. [2]. Bymaster FP, Katner JS, Nelson DL et al. Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2002 Nov;27(5):699-711. |
