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2482-25-9-4-Hydroxyhippuric Acid 4-Hydroxyhippuric Acid

4-Hydroxyhippuric Acid

For research use only. Not for therapeutic Use.

  • CAT Number: R036353
  • CAS Number: 2482-25-9
  • Molecular Formula: C9H9NO4
  • Molecular Weight: 195.174
  • Purity: ≥95%
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Related Small Molecules: RADICININ FROM ALTERNARIA CHRYSANTHEMI     Baccatin III     lasiocarpine N-oxide    

4-Hydroxyhippuric Acid (CAS&nbsp;2482-25-9), also known as&nbsp;p-Hydroxyhippuric Acid,&nbsp;<span style="font-size: 16px; font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;"><span style="color: rgb(0, 0, 0); font-size: 12px; font-family: arial, helvetica, sans-serif;">is a dihydroxy phenolic acid inhibitor of organic anion transporter 1 (IC</span><sub style="color: rgb(0, 0, 0); font-family: arial, helvetica, sans-serif; box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; bottom: -0.25em;">50</sub><span style="color: rgb(0, 0, 0); font-size: 12px; font-family: arial, helvetica, sans-serif;">&nbsp;= 25 &micro;M in opossum kidney cells).It increases the production of free radicals in opossum kidney cells expressing human OAT1.&nbsp;</span><em style="color: rgb(0, 0, 0); font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box;">p</em><span style="color: rgb(0, 0, 0); font-size: 12px; font-family: arial, helvetica, sans-serif;">-Hydroxyhippuric acid reduces the secretion of TNF-&alpha;, but not IL-1&beta; or IL-6, in isolated human peripheral blood mononuclear cells (PBMCs) stimulated with LPS by 30.4% when used at a concentration of 1 &micro;M.</span></span>
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<span style="font-size: 16px; font-family: -apple-system, system-ui, &quot;Segoe UI&quot;, Roboto, Oxygen, Oxygen-Sans, Ubuntu, Cantarell, &quot;Fira Sans&quot;, &quot;Droid Sans&quot;, &quot;Helvetica Neue&quot;, &quot;Source Sans Pro&quot;, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;"><sup class="referenceList" style="box-sizing: border-box; position: relative; font-size: 12px; line-height: 0; top: -0.5em;"></sup></span></span></span></div>


Catalog Number R036353
CAS Number 2482-25-9
Synonyms

N-(4-Hydroxybenzoyl)glycine; 4-Hydroxybenzoylglycine; N-(p-Hydroxybenzoyl)glycine; p-Hydroxyhippuric Acid

Molecular Formula C9H9NO4
Purity ≥95%
Target Endogenous metabolite
Storage Desiccate at -20C
IUPAC Name 2-[(4-hydroxybenzoyl)amino]acetic acid
InChI InChI=1S/C9H9NO4/c11-7-3-1-6(2-4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
InChIKey ZMHLUFWWWPBTIU-UHFFFAOYSA-N
SMILES C1=CC(=CC=C1C(=O)NCC(=O)O)O
Reference

<p class="reference" data-reference="48924" data-reference-type="Journal Article" style="font-size: 16px; box-sizing: border-box; margin-top: 0px; margin-bottom: 1rem; font-family: Lato, &quot;Lucida Grande&quot;, &quot;Lucida Sans Unicode&quot;, &quot;Lucida Sans&quot;, Geneva, Verdana, sans-serif; font-variant-ligatures: normal; orphans: 2; widows: 2;">
<span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:12px;"><span style="box-sizing: border-box;">1.&nbsp;</span><span class="authors" data-text="Motojima, M., Hosokawa, A., Yamato, H., et al." style="box-sizing: border-box;">Motojima, M., Hosokawa, A., Yamato, H.,&nbsp;<span class="foreign" style="box-sizing: border-box; font-style: italic;">et al</span>.</span><span class="title" data-text="Uraemic toxins induce proximal tubular injury via organic anion transporter 1-mediated uptake." style="box-sizing: border-box;">&nbsp;<span style="box-sizing: border-box;"><span class="scientificMarkup" style="box-sizing: border-box;">Uraemic toxins induce proximal tubular injury&nbsp;<span class="foreign" style="box-sizing: border-box; font-style: italic;">via</span>&nbsp;organic anion transporter 1-<wbr style="box-sizing: border-box;" />mediated uptake.</span></span></span><span class="journal" style="box-sizing: border-box; font-style: italic;">&nbsp;Br. J. Pharmacol.</span><span class="number" style="box-sizing: border-box; font-weight: 700;">&nbsp;</span><span class="pagerange" style="box-sizing: border-box;">135(2),555-563</span><span class="year" style="box-sizing: border-box;">&nbsp;(2002)</span>.</span></span><br />
<span style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box;">2.&nbsp;</span><span class="authors" data-text="Monagas, M., Khan, N., Andrés-Lacueva, C., et al." style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box;">Monagas, M., Khan, N., Andr&eacute;s-<wbr style="box-sizing: border-box;" />Lacueva, C.,&nbsp;<span class="foreign" style="box-sizing: border-box; font-style: italic;">et al</span>.</span><span class="title" data-text="Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-stimulated cytokine secretion by human peripheral blood mononuclear cells" style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box;">&nbsp;<span style="box-sizing: border-box;"><span class="scientificMarkup" style="box-sizing: border-box;">Dihydroxylated phenolic acids derived from microbial metabolism reduce lipopolysaccharide-<wbr style="box-sizing: border-box;" />stimulated cytokine secretion by human peripheral blood mononuclear cells</span></span>.</span><span class="journal" style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box; font-style: italic;">&nbsp;Br. J. Nutr.</span><span class="number" style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box; font-weight: 700;">&nbsp;</span><span class="pagerange" style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box;">102(2), 201-206</span><span class="year" style="font-size: 12px; font-family: arial, helvetica, sans-serif; box-sizing: border-box;">&nbsp;(2009)</span><span style="font-size: 12px; font-family: arial, helvetica, sans-serif;">.</span></p>

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