For research use only. Not for therapeutic Use.
4-IBP is a selective σ1 agonist, binding to σ1 receptors with high affinity (Ki = 1.7 nM) and with slightly weaker affinity to σ2 receptors (Ki = 25.2 nM).
| Catalog Number | I001977 |
| CAS Number | 155798-08-6 |
| Synonyms | N-(1-benzylpiperidin-4-yl)-4-iodobenzamide |
| Molecular Formula | C19H21IN2O |
| Purity | ≥95% |
| InChI | InChI=1S/C19H21IN2O/c20-17-8-6-16(7-9-17)19(23)21-18-10-12-22(13-11-18)14-15-4-2-1-3-5-15/h1-9,18H,10-14H2,(H,21,23) |
| InChIKey | HELCSESNNDZLFM-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1NC(=O)C2=CC=C(C=C2)I)CC3=CC=CC=C3 |
| Reference | [1]. Mégalizzi V, et al. 4-IBP, a sigma1 receptor agonist, decreases the migration of human cancer cells, including glioblastoma cells, in vitro and sensitizes them in vitro and in vivo to cytotoxic insults of proapoptotic and proautophagic drugs. Neoplasia. 2007 May;9(5):358-69. |
