For research use only. Not for therapeutic Use.
Potent and selective histamine H4 agonist
| CAS Number | 36376-47-3 |
| Molecular Formula | C6H11N3.2HCl |
| Purity | ≥95% |
| IUPAC Name | 2-(5-methyl-1H-imidazol-4-yl)ethanamine;dihydrochloride |
| InChI | InChI=1S/C6H11N3.2ClH/c1-5-6(2-3-7)9-4-8-5;;/h4H,2-3,7H2,1H3,(H,8,9);2*1H |
| SMILES | CC1=C(N=CN1)CCN.Cl.Cl |
| Reference | RK Morgan et al. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J. Immunol. 2007, 178(12), 8081-9.
Dijkstra, D. et al. Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J Allergy Clin Immunol. 2007, 120(2), 300-7.
Lim et al. Evaluation of histamine H1- H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J. Pharmacol. Exp. Ther. 2005, 314, 1310. |
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