4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

• CAT Number: R000254
• CAS Number: 64091-91-4
• Molecular Formula: C10H13N3O2
• Molecular Weight: 207.23
• Purity: ≥95%
• Synonyms: 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; NNK
• Target: Metabolic Enzyme/Protease
• Storage: Store at RT
• IUPAC Name: N-methyl-N-(4-oxo-4-pyridin-3-ylbutyl)nitrous amide
• InChI: InChI=1S/C10H13N3O2/c1-13(12-15)7-3-5-10(14)9-4-2-6-11-8-9/h2,4,6,8H,3,5,7H2,1H3
• InChIKey: FLAQQSHRLBFIEZ-UHFFFAOYSA-N
• SMILES: CN(CCCC(=O)C1=CN=CC=C1)N=O

4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (Cat No.:R000254) is a potent carcinogenic nitrosamine found in tobacco and tobacco smoke. It is a major contributor to the carcinogenicity of tobacco products, particularly lung cancer. NNK is metabolically activated in the body to form reactive intermediates that can bind to DNA, leading to the formation of DNA adducts. These adducts can induce mutations and ultimately contribute to the development of cancer. NNK is a well-studied compound in cancer research and is used as a model carcinogen to understand the mechanisms of carcinogenesis and develop strategies for cancer prevention and treatment.