For research use only. Not for therapeutic Use.
(4-NH2)-Exatecan, a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) (US20200306243A1, compound A)[1].
(4-NH2)-Exatecan contains a linker for connecting to a Ligand Unit, wherein the linker is attached in a cleavable manner to the amino residue, characterized by the addition of an amino (NH2) functional group at the 4th position of the parent molecule[1].
| Catalog Number | I045139 |
| CAS Number | 2495742-21-5 |
| Synonyms | (10S)-19-amino-10-ethyl-10-hydroxy-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16(24),17,19-heptaene-5,9-dione |
| Molecular Formula | C23H21N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H21N3O4/c1-2-23(29)15-8-18-20-13(9-26(18)21(27)14(15)10-30-22(23)28)11-4-3-5-12-16(24)6-7-17(25-20)19(11)12/h6-8,29H,2-5,9-10,24H2,1H3/t23-/m0/s1 |
| InChIKey | VMSFUDYSPMXQSY-QHCPKHFHSA-N |
| SMILES | CCC1(C2=C(COC1=O)C(=O)N3CC4=C5CCCC6=C(C=CC(=C56)N=C4C3=C2)N)O |
| Reference | [1]. Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1. |
