4-Nitrophenyl Phenylphosphonate

• CAT Number: R065549
• CAS Number: 57072-35-2
• Molecular Formula: C12H10NO5P
• Molecular Weight: 279.188
• Purity: ≥95%
• Synonyms: bis(4-Nitrophenyl) Phenylphosphonate;p-Nitrophenyl Phenylphosphonate;NPPP
• Storage: -20°C
• InChI: InChI=1S/C12H10NO5P/c14-13(15)10-6-8-11(9-7-10)18-19(16,17)12-4-2-1-3-5-12/h1-9H,(H,16,17)
• InChIKey: NRGZTHQFAQCJCQ-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)P(=O)(O)OC2=CC=C(C=C2)[N+](=O)[O-]

4-Nitrophenyl phenylphosphonate is a substrate for 5’-nucleotide phosphodiesterases. It is a more preferable substrate to 5’-nucleotide phosphodiesterases than naturally occurring nucleotides or bis(4-nitrophenyl) phosphate because of its stability, ease of synthesis, and higher rate of hydrolysis under saturating conditions.

Reference

1.Moe, O.A., Jr. and Butler, L.G. The catalytic mechanism of bovine intestinal 5/’-nucleotide phosphodiesterase. pH and inhibition studies. The Journal of Biological Chemisty 258(11), 6941-6946 (1983).