For research use only. Not for therapeutic Use.
4P-PDOT, also known as 4-phenyl-2- propionamidotetralin, is a MT2-receptor-specific antagonist. MT2 melatonin receptor may be a novel target for analgesic drug development.
| Catalog Number | M110319 |
| CAS Number | 134865-74-0 |
| Synonyms | N-((2R,4R)-4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide |
| Molecular Formula | C19H21NO |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at RT |
| InChI | InChI=1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21)/t16-,18+/m0/s1 |
| InChIKey | RCYLUNPFECYGDW-UHFFFAOYSA-N |
| SMILES | O=C(CC)NC1CC(C2=CC=CC=C2)C3=C(C=CC=C3)C1 |
| Reference | </br>1:The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo studies. Juszczak M, Roszczyk M, Kowalczyk E, Stempniak B.J Physiol Pharmacol. 2014 Dec;65(6):777-84. PMID: 25554981 Free Article</br>2:An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): a selective MT(2) melatonin receptor antagonist. Lucarini S, Bedini A, Spadoni G, Piersanti G.Org Biomol Chem. 2008 Jan 7;6(1):147-50. Epub 2007 Nov 13. PMID: 18075659 |
