For research use only. Not for therapeutic Use.
4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research[1].
| Catalog Number | I044125 |
| CAS Number | 2243355-51-1 |
| Synonyms | N-[(E)-pyridin-4-ylmethylideneamino]-4-(quinolin-4-ylamino)benzamide |
| Molecular Formula | C22H17N5O |
| Purity | ≥95% |
| InChI | InChI=1S/C22H17N5O/c28-22(27-25-15-16-9-12-23-13-10-16)17-5-7-18(8-6-17)26-21-11-14-24-20-4-2-1-3-19(20)21/h1-15H,(H,24,26)(H,27,28)/b25-15+ |
| InChIKey | AVTFCFMDUCRAQC-MFKUBSTISA-N |
| SMILES | C1=CC=C2C(=C1)C(=CC=N2)NC3=CC=C(C=C3)C(=O)NN=CC4=CC=NC=C4 |
| Reference | [1]. Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651. |
