4-(tert-Butyl)-benzhydroxamic Acid

• CAT Number: R041503
• CAS Number: 62034-73-5
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.24
• Purity: ≥95%
• Synonyms: 4-tert-butyl-N-hydroxybenzamide
• InChI: InChI=1S/C11H15NO2/c1-11(2,3)9-6-4-8(5-7-9)10(13)12-14/h4-7,14H,1-3H3,(H,12,13)
• InChIKey: HVTKRCPHQXJOFW-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC=C(C=C1)C(=O)NO

4-(tert-Butyl)-benzhydroxamic Acid is a PqsR antagonist with IC50s of 12.5 μM and 23.6 μM for E. coli and P. aeruginosa, respectively. 4-(tert-Butyl)-benzhydroxamic Acid reduces the production of the virulence factor pyocyanin in P. aeruginosa with an IC50 of 87.2 μM[1].

Reference

[1]. Klein T, et al. Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptionalregulator PqsR: biophysically guided hit discovery and optimization. ACS Chem Biol. 2012 Sep 21;7(9):1496-501.
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