4-Thio-2’-deoxyuridine

• CAT Number: I041249
• CAS Number: 5580-20-1
• Molecular Formula: C9H12N2O4S
• Molecular Weight: 244.27
• Purity: ≥95%
• Synonyms: 1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
• IUPAC Name: 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
• InChI: InChI=1S/C9H12N2O4S/c12-4-6-5(13)3-8(15-6)11-2-1-7(16)10-9(11)14/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,16)/t5-,6+,8+/m0/s1
• InChIKey: PHNDUXLWAVSUAL-SHYZEUOFSA-N
• SMILES: C1[C@@H]([C@H](O[C@H]1N2C=CC(=S)NC2=O)CO)O

4-Thio-2’-deoxyuridine（Cat No.:I041249）is a nucleoside analog that incorporates a sulfur atom in place of the oxygen atom at the 4-position of the pyrimidine ring of 2′-deoxyuridine. This modification enhances its ability to interfere with nucleic acid metabolism, inhibiting DNA synthesis and repair mechanisms. It is primarily used in molecular biology research to study DNA replication, repair, and cell cycle regulation. Additionally, 4-Thio-2′-deoxyuridine has potential therapeutic applications in cancer treatment, where its incorporation into DNA can induce DNA damage and promote cell death, particularly in rapidly dividing tumor cells.