4-Thio-2’-deoxyuridine

• CAT Number: I041249
• CAS Number: 5580-20-1
• Molecular Formula: C9H12N2O4S
• Molecular Weight: 244.27
• Purity: ≥95%
• Synonyms: 1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
• InChI: InChI=1S/C9H12N2O4S/c12-4-6-5(13)3-8(15-6)11-2-1-7(16)10-9(11)14/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,16)/t5?,6-,8-/m1/s1
• InChIKey: PHNDUXLWAVSUAL-KYVYOHOSSA-N
• SMILES: C1C(C(OC1N2C=CC(=S)NC2=O)CO)O

4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Reference

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
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