4-Thiothymidine

• CAT Number: I041244
• CAS Number: 7236-57-9
• Molecular Formula: C10H14N2O4S
• Molecular Weight: 258.29
• Purity: ≥95%
• Synonyms: 1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-4-sulfanylidenepyrimidin-2-one
• InChI: InChI=1S/C10H14N2O4S/c1-5-3-12(10(15)11-9(5)17)8-2-6(14)7(4-13)16-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,17)/t6?,7-,8-/m1/s1
• InChIKey: AVKSPBJBGGHUMW-SPDVFEMOSA-N
• SMILES: CC1=CN(C(=O)NC1=S)C2CC(C(O2)CO)O

4-Thiothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Reference

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
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