4,4’-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide(Atenolol Impurity E)

• CAT Number: R040051
• CAS Number: 141650-31-9
• Molecular Formula: C19H22N2O5
• Molecular Weight: 358.394
• Purity: ≥95%
• Synonyms: Atenolol Impurity E; Atenolol Bis Ether
• Storage: -20°C
• IUPAC Name: 2-[4-[3-[4-(2-amino-2-oxoethyl)phenoxy]-2-hydroxypropoxy]phenyl]acetamide
• InChI: InChI=1S/C19H22N2O5/c20-18(23)9-13-1-5-16(6-2-13)25-11-15(22)12-26-17-7-3-14(4-8-17)10-19(21)24/h1-8,15,22H,9-12H2,(H2,20,23)(H2,21,24)
• InChIKey: RJTRBVLDVHIXNJ-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CC(=O)N)OCC(COC2=CC=C(C=C2)CC(=O)N)O

4,4’-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis-benzeneacetamide, also known as Atenolol Impurity E, is a chemical byproduct or degradation product formed during the synthesis or storage of atenolol, a beta-blocker used to treat cardiovascular conditions. This impurity features a bis-benzeneacetamide structure connected by a hydroxypropanediol linkage, and its identification is crucial for ensuring the purity and safety of pharmaceutical formulations. Monitoring and controlling such impurities are essential in drug manufacturing to comply with regulatory standards and maintain drug efficacy and patient safety.