4,4/'-Diphenylmethane diisocyanate

• CAT Number: M069572
• CAS Number: 101-68-8
• Molecular Formula: C15H10N2O2
• Molecular Weight: 250.257
• Purity: ≥95%
• Synonyms: Diphenylmethane diisocyanate; Bis(4-isocyanatophenyl)methane; Isonate
• Storage: -20°C
• IUPAC Name: 1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
• InChI: InChI=1S/C15H10N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h1-8H,9H2
• InChIKey: UPMLOUAZCHDJJD-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O

4,4/'-Diphenylmethane diisocyanate (CAS 101-68-8) is a diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions. It has a role as a hapten and an allergen. It derives from a hydride of a diphenylmethane.

Reference

1.Herrick, Christina A., et al. "A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge." Journal of allergy and clinical immunology 109.5 (2002): 873-878.
2.Lushniak, Boris D., et al. "Indirect assessment of 4, 4′‐diphenylmethane diisocyanate (MDI) exposure by evaluation of specific humoral immune responses to MDI conjugated to human serum albumin." American journal of industrial medicine 33.5 (1998): 471-477.