4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

• CAT Number: C000459
• CAS Number: 1770812-37-7
• Molecular Formula: C₁₉H₁₇Cl₂N₃O₅S
• Molecular Weight: 470.33
• Purity: ≥95%
• Synonyms: (S)-4,5-Dichloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Off-White Solid
• Storage: 4°C

4,5-Dichloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide(CAT: C000459) is a compound of significance within the realm of antithrombotic medications. Serving as an impurity of Rivaroxaban, a novel, and potent direct Factor Xa (FXa) inhibitor, this compound’s presence highlights the importance of monitoring purity in drug formulations. Rivaroxaban’s role as an antithrombotic agent stems from its ability to selectively inhibit FXa, contributing to thrombosis prevention. The understanding of associated impurities like this compound aids in maintaining the safety and efficacy of the drug.

Reference

Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),