4E2RCat

• CAT Number: I013746
• CAS Number: 432499-63-3
• Molecular Formula: C₂₂H₁₄ClNO₄S₂
• Molecular Weight: 455.93
• Purity: ≥95%
• Target: Eukaryotic Initiation Factor (eIF)
• Solubility: DMSO: 15.5 mg/mL
• IUPAC Name: 5-[5-[(Z)-(3-benzyl-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]-2-chlorobenzoic acid
• InChI: InChI=1S/C22H14ClNO4S2/c23-17-8-6-14(10-16(17)21(26)27)18-9-7-15(28-18)11-19-20(25)24(22(29)30-19)12-13-4-2-1-3-5-13/h1-11H,12H2,(H,26,27)/b19-11-
• InChIKey: WOBPZFKXPCYOLU-ODLFYWEKSA-N
• SMILES: C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC(=C(C=C4)Cl)C(=O)O)SC2=S

4E2RCat（Cat No.:I013746）is a potent and selective inhibitor of IκB kinase (IKK) subunit β, essential for NF-κB signaling. By targeting this key enzyme, 4E2RCat blocks the phosphorylation and degradation of IκB proteins, thus preventing the activation of NF-κB. This pathway plays a crucial role in regulating immune responses, inflammation, and cell survival, making 4E2RCat a valuable tool in studying these processes. Its specificity toward IKKβ makes it useful for exploring inflammatory diseases, cancer, and other conditions where NF-κB dysregulation is implicated, offering potential therapeutic insights.

Reference

[1]. Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9.