4N1K peptide

• CAT Number: I040750
• CAS Number: 178921-95-4
• Molecular Formula: C68H105N17O12S
• Molecular Weight: 1384.73
• Purity: ≥95%
• Synonyms: (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoyl]amino]hexanoic acid
• InChI: InChI=1S/C68H105N17O12S/c1-40(2)56(65(94)79-51(30-35-98-5)61(90)83-55(38-44-39-76-48-22-10-9-20-46(44)48)63(92)78-49(23-12-15-32-70)59(88)80-52(67(96)97)24-13-16-33-71)85-66(95)57(41(3)4)84-64(93)54(37-43-26-28-45(86)29-27-43)82-62(91)53(36-42-18-7-6-8-19-42)81-60(89)50(25-17-34-75-68(73)74)77-58(87)47(72)21-11-14-31-69/h6-10,18-20,22,26-29,39-41,47,49-57,76,86H,11-17,21,23-25,30-38,69-72H2,1-5H3,(H,77,87)(H,78,92)(H,79,94)(H,80,88)(H,81,89)(H,82,91)(H,83,90)(H,84,93)(H,85,95)(H,96,97)(H4,73,74,75)/t47-,49-,50-,51-,52-,53-,54-,55-,56-,57-/m0/s1
• InChIKey: XEMLJJZYMPZGBS-ITJFCMOYSA-N
• SMILES: CC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCSC)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C(CC4=CC=CC=C4)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)N

4N1K peptide(CAT: I040750) (sequence: KRFYVVMWKK) is a synthetic peptide derived from the C-terminal domain of thrombospondin-1 (TSP-1), specifically the CD47-binding region. It functions as a CD47 agonist, modulating cell signaling related to adhesion, migration, and apoptosis. 4N1K is widely used in cancer and immunology research to study the CD47-SIRPα pathway, tumor immune evasion, and angiogenesis. It can influence integrin activation and mediate effects on immune cell function and tumor cell behavior. With high purity and biological activity, the 4N1K peptide is ideal for in vitro assays and mechanistic studies of cell-matrix and immune interactions.