4SC-202

For research use only. Not for therapeutic Use.

  • CAT Number: I000667
  • CAS Number: 1186222-89-8
  • Molecular Formula: C₃₀H₂₉N₅O₆S₂
  • Molecular Weight: 619.71
  • Purity: ≥95%
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4SC-202(Cat No.:I000667)is a potent and selective inhibitor of the enzyme histone deacetylase 1 (HDAC1), known for its role in regulating gene expression through histone modification. This compound has shown promise in cancer therapy, particularly in hematologic malignancies, by promoting cell differentiation and apoptosis in tumor cells. By selectively inhibiting HDAC1, 4SC-202 enhances the acetylation of histones, leading to the reactivation of tumor suppressor genes. Ongoing clinical studies aim to evaluate its efficacy and safety, positioning 4SC-202 as a potential therapeutic candidate in the growing field of epigenetic cancer treatments.


Catalog Number I000667
CAS Number 1186222-89-8
Molecular Formula C₃₀H₂₉N₅O₆S₂
Purity ≥95%
Target Epigenetics
Solubility DMSO: ≥ 51 mg/mL
Storage Store at -20°C
IUPAC Name (E)-N-(2-aminophenyl)-3-[1-[4-(1-methylpyrazol-4-yl)phenyl]sulfonylpyrrol-3-yl]prop-2-enamide;4-methylbenzenesulfonic acid
InChI InChI=1S/C23H21N5O3S.C7H8O3S/c1-27-16-19(14-25-27)18-7-9-20(10-8-18)32(30,31)28-13-12-17(15-28)6-11-23(29)26-22-5-3-2-4-21(22)24;1-6-2-4-7(5-3-6)11(8,9)10/h2-16H,24H2,1H3,(H,26,29);2-5H,1H3,(H,8,9,10)/b11-6+;
InChIKey IAVXAZDVNICKFJ-ICSBZGNSSA-N
SMILES CC1=CC=C(C=C1)S(=O)(=O)O.CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N
Reference

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<br>[1]. S.W.Henning, et al. Preclinical characterization of 4SC-202, a noval isotype specific HDAC inhibitor
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