5-Aminovaleric acid

• CAT Number: I019908
• CAS Number: 660-88-8
• Molecular Formula: C5H11NO2
• Molecular Weight: 117.15
• Purity: ≥95%
• Synonyms: 5-aminopentanoic acid
• InChI: InChI=1S/C5H11NO2/c6-4-2-1-3-5(7)8/h1-4,6H2,(H,7,8)
• InChIKey: JJMDCOVWQOJGCB-UHFFFAOYSA-N
• SMILES: C(CCN)CC(=O)O

5-Aminovaleric acid is believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist.
5-Aminovaleric acid is a normal metabolite present in human saliva, with a tendency to elevated concentration in patients with chronic periodontitis[1]. 5-Aminovaleric acid is also believed to act as a methylene homologue of gamma-aminobutyric acid (GABA) and functions as a weak GABA agonist[2]. It is also known as an antifibrinolytic amino acid analog and so it functions as a weak inhibitor of the blood clotting pathway[3].

Reference

[1]. Syrjänen S, et al. Free amino-acid content of wax-stimulated human whole saliva as related to periodontal disease. Arch Oral Biol. 1987;32(9):607-10.
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[2]. Callery PS, et al. 1-Piperideine as an in vivo precursor of the gamma-aminobutyric acid homologue 5-aminopentanoic acid. J Neurochem. 1985 Sep;45(3):946-8.
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[3]. Cole KR, et al. The binding of antifibrinolytic amino acids to kringle-4-containing fragments of plasminogen. Arch Biochem Biophys. 1984 Mar;229(2):568-75.
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