5-APDB (hydrochloride)

• CAT Number: R058840
• CAS Number: 152623-94-4
• Molecular Formula: C11H16ClNO
• Molecular Weight: 213.705
• Purity: ≥95%
• Synonyms: 5-(2-Aminopropyl)-2,3-dihydrobenzofuran;EMA-4;3-desoxy-MDA
• Storage: -20°C
• IUPAC Name: 1-(2,3-dihydro-1-benzofuran-5-yl)propan-2-amine;hydrochloride
• InChI: InChI=1S/C11H15NO.ClH/c1-8(12)6-9-2-3-11-10(7-9)4-5-13-11;/h2-3,7-8H,4-6,12H2,1H3;1H
• InChIKey: BZKLFXQUBIRXAK-UHFFFAOYSA-N
• SMILES: CC(CC1=CC2=C(C=C1)OCC2)N.Cl

5-<wbr></wbr>APDB is an entactogen belonging to the amphetamine and the phenethylamine classes. It is an analog of MDA where the heterocyclic 3-<wbr></wbr>position oxygen from the 3,4-<wbr></wbr>methylenedioxy ring has been replaced by a methylene group. 5-<wbr></wbr>APDB can inhibit serotonin, dopamine and norepinephrine reuptake with IC50 values of 0.13, 7.1, and 3.2 µM, respectively, and generalizes closely to the non-<wbr></wbr>stimulant MDMA analogs, MBDB and MMAI, in drug discrimination studies. This product is intended for forensic purposes.

Reference

1.Monte, A.P.,Marona-Lewicka, D.,Cozzi, N.V., et al. Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine. Journal of Medicinal Chemistry 36, 3700-3706 (1993).