For research use only. Not for therapeutic Use.
5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].
5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1].
| Catalog Number | M047303 |
| CAS Number | 1453-97-0 |
| Synonyms | N,N-dimethyl-1-(5-phenylmethoxy-1H-indol-3-yl)methanamine |
| Molecular Formula | C18H20N2O |
| Purity | ≥95% |
| InChI | InChI=1S/C18H20N2O/c1-20(2)12-15-11-19-18-9-8-16(10-17(15)18)21-13-14-6-4-3-5-7-14/h3-11,19H,12-13H2,1-2H3 |
| InChIKey | POTVAILTNPOQJH-UHFFFAOYSA-N |
| SMILES | CN(C)CC1=CNC2=C1C=C(C=C2)OCC3=CC=CC=C3 |
| Reference | [1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141. |
