5-Ethyluracil

• CAT Number: M008447
• CAS Number: 4212-49-1
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.142
• Purity: ≥95%
• Synonyms: HOMOTHYMINE;AURORA KA-580;5-ETHYLURACIL;2,4-DIHYDROXY-5-ETHYLPYRIMIDINE;5-Ethyl-1H-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 5-ethyl- (9CI);DIHYDROXY-5-ETHYLPYRIMIDINE;5-ethvluracil
• Storage: room temp
• IUPAC Name: 5-ethyl-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C6H8N2O2/c1-2-4-3-7-6(10)8-5(4)9/h3H,2H2,1H3,(H2,7,8,9,10)
• InChIKey: RHIULBJJKFDJPR-UHFFFAOYSA-N
• SMILES: CCC1=CNC(=O)NC1=O

Reference

1: Mansuri MM, Ghazzouli I, Chen MS, Howell HG, Brodfuehrer PR, Benigni DA,
Martin JC. 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil. A highly
selective antiherpes simplex agent. J Med Chem. 1987 May;30(5):867-71. PubMed
PMID: 3033244.

2: Swierkowski M, Shugar D. A new thymine base analogue, 5-ethyluracil:
5-ethyluridine-5/’-pyrophosphate and poly-5-ethyluridylic acid. Acta Biochim Pol.
1969;16(3):263-77. PubMed PMID: 4904852.

3: Piechowska M, Shugar D. Replacement of 5-methyluracil (thymine) by
5-ethyluracil in bacterial DNA. Biochem Biophys Res Commun. 1965 Sep
22;20(6):768-73. PubMed PMID: 5324103.

4: Kaul R, Kiefer G, Erhardt S, Hempel B.
2-14C-1-(2/’-deoxy-beta-D-ribofuranosyl)-5-ethyluracil: synthesis and
biotransformation in rats. J Pharm Sci. 1980 May;69(5):531-4. PubMed PMID:
7381737.

5: Kulikowski T, Zawadzki Z, Shugar D, Descamps J, De Clercq E. Synthesis and
antiviral activities of arabinofuranosyl-5-ethylpyrimidine nucleosides. Selective
antiherpes activity of 1-(beta-D-arabinofuranosyl)-5-ethyluracil. J Med Chem.
1979 Jun;22(6):647-53. PubMed PMID: 222908.