For research use only. Not for therapeutic Use.
2-Amino-5-fluorobenzoic acid is a toxic antimetabolite for the tryptophan pathway in yeast that can be used to counterselect for <em>TRP1</em>, a commonly used genetic marker in <em>S. cerevisiae</em>. Because this <em>trp1</em> strain lacks the enzymes required for the conversion of anthranilic acid to tryptophan, it is resistant to 2-amino-5-fluorobenzoic acid feedback inhibition, enabling a growth-based, positive selection of the <em>TRP1</em> marker. 2-Amino-5-fluorobenzoic acid is frequently used in genetic procedures that involve plasmid manipulations.
Catalog Number | R001241 |
CAS Number | 446-08-2 |
Synonyms | 2-Amino-5-fluorobenzoic Acid, 5-FAA |
Molecular Formula | C7H6FNO2 |
Purity | ≥95% |
Storage | -20°C |
IUPAC Name | 2-amino-5-fluorobenzoic acid |
InChI | InChI=1S/C7H6FNO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,9H2,(H,10,11) |
InChIKey | FPQMGQZTBWIHDN-UHFFFAOYSA-N |
SMILES | C1=CC(=C(C=C1F)C(=O)O)N |