5-Fluoroorotic acid

• CAT Number: I011219
• CAS Number: 703-95-7
• Molecular Formula: C5H3FN2O4
• Molecular Weight: 174.09
• Purity: ≥95%
• Synonyms: 5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
• Target: Fungal
• Solubility: Soluble to 100 mM in 4M NH4OH and to 100 mM in DMSO
• Storage: -20°C
• IUPAC Name: 5-fluoro-2,4-dioxo-1H-pyrimidine-6-carboxylic acid
• InChI: InChI=1S/C5H3FN2O4/c6-1-2(4(10)11)7-5(12)8-3(1)9/h(H,10,11)(H2,7,8,9,12)
• InChIKey: SEHFUALWMUWDKS-UHFFFAOYSA-N
• SMILES: C1(=C(NC(=O)NC1=O)C(=O)O)F

5-Fluoroorotic Acid（Cat No.:I011219）is a fluorinated derivative of orotic acid, commonly used in biochemical and pharmaceutical research. It serves as a potent inhibitor of pyrimidine biosynthesis by interfering with the enzyme dihydroorotate dehydrogenase. This inhibition disrupts the production of uridine monophosphate (UMP), a key precursor for RNA and DNA synthesis. Due to its ability to selectively target rapidly proliferating cells, 5-Fluoroorotic Acid is explored for its potential in cancer research and as an antifungal agent. It is also valuable for studies in metabolic control and genetic expression analysis.