5-Fluorouracil-6-d1

• CAT Number: R010887
• CAS Number: 90344-84-6
• Molecular Formula: C4H3FN2O2
• Molecular Weight: 131.08
• Purity: ≥95%
• Synonyms: 5-Fluoro-2,4(1H,3H)pyrimidinedione-d1; 2,4-Dihydroxy-5-fluoropyrimidine-d1; 5-FU-d1; 5-Fluoropyrimidine-2,4-diol-d1; Adrucil-d1; Arumel-d1; Carac-d1; Fluoroplex-d1; Fluorouracil-d1; Flurablastin-d1; Queroplex-d1; Ro 2-9757-d1; Timazin-d1; U 8953-d1
• Target: Anti-infection
• Storage: Store at 4°C
• IUPAC Name: 6-deuterio-5-fluoro-1H-pyrimidine-2,4-dione
• InChI: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)/i1D
• InChIKey: GHASVSINZRGABV-MICDWDOJSA-N
• SMILES: C1=C(C(=O)NC(=O)N1)F

5-Fluorouracil-6-d1（Cat No.:R010887）is a deuterated form of 5-fluorouracil (5-FU), a widely used chemotherapeutic agent. It works by inhibiting thymidylate synthase, an enzyme critical for DNA synthesis, leading to disruption of DNA replication and cell division, particularly in rapidly dividing cancer cells. The incorporation of deuterium in 5-Fluorouracil-6-d1 enhances its metabolic stability, potentially improving its pharmacokinetics and therapeutic efficacy. 5-FU and its derivatives, including 5-Fluorouracil-6-d1, are extensively used in the treatment of cancers such as colorectal, breast, and head and neck cancers, making it a vital compound in oncology research.