5'-Guanylic acid

• CAT Number: I019919
• CAS Number: 85-32-5
• Molecular Formula: C₁₀H₁₄N₅O₈P
• Molecular Weight: 363.22
• Purity: ≥95%
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
• InChI: InChI=1S/C10H14N5O8P/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
• InChIKey: RQFCJASXJCIDSX-UUOKFMHZSA-N
• SMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)O)N=C(NC2=O)N

5′-Guanylic acid (Cat No.:I019919) is a nucleotide involved in various metabolic disorders. In the AICA-ribosiduria pathway, defects in AMP deaminase result in the accumulation of 5′-GMP. Adenosine deaminase deficiency leads to the buildup of 5′-GMP, causing severe combined immunodeficiency (SCID). Adenine phosphoribosyltransferase deficiency (APRT) results in the accumulation of 5′-GMP, leading to kidney stones and renal failure. Additionally, in the 2-hydroxybutyric aciduria pathway, mutations in 2-hydroxyglutarate dehydrogenase cause the accumulation of 5′-GMP, contributing to neurological symptoms.