5-HT3 antagonist 5

• CAT Number: I042912
• CAS Number: 901599-43-7
• Molecular Formula: C16H13N3O2
• Molecular Weight: 279.29
• Purity: ≥95%
• Synonyms: N-(4-methoxyphenyl)quinoxaline-2-carboxamide
• InChI: InChI=1S/C16H13N3O2/c1-21-12-8-6-11(7-9-12)18-16(20)15-10-17-13-4-2-3-5-14(13)19-15/h2-10H,1H3,(H,18,20)
• InChIKey: UUFCEPQEIQOEAL-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)NC(=O)C2=NC3=CC=CC=C3N=C2

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice[1].
5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5[1].
5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice[1].

Reference

[1]. Mahesh R, et al. Design, synthesis and structure-activity relationship of novel quinoxalin-2-carboxamides as 5-HT3 receptor antagonists for the management of depression. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6773-6.
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