For research use only. Not for therapeutic Use.
Selective brain penetrant 5-HT6 receptor antagonist (pKi value 8.6). Close regio-isomer of SB 699929 with brain–blood ratio of 2.6:1 and ED50 value of 5 mg/kg (po), and thus twice as potent as SB 271046 (Axon 1099).
| Catalog Number | I047545 |
| CAS Number | 497963-70-9 |
| Molecular Formula | C19H20ClN3O2S.HCl |
| Purity | ≥95% |
| IUPAC Name | 3-(4-chlorophenyl)sulfonyl-1-methyl-7-piperazin-1-ylindole;hydrochloride |
| InChI | InChI=1S/C19H20ClN3O2S.ClH/c1-22-13-18(26(24,25)15-7-5-14(20)6-8-15)16-3-2-4-17(19(16)22)23-11-9-21-10-12-23;/h2-8,13,21H,9-12H2,1H3;1H |
| SMILES | CN1C=C(C2=C1C(=CC=C2)N3CCNCC3)S(=O)(=O)C4=CC=C(C=C4)Cl.Cl |
| Reference | M. Ahmed et al. Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists. Bioorg. Med. Chem. Lett. 2005, 15, 4867-4871. |
