5-Hydroxy Propafenone Hydrochloride

• CAT Number: C000794
• CAS Number: 86383-32-6
• Molecular Formula: C₂₁H₂₇NO₄ • HCl
• Molecular Weight: 393.9
• Purity: ≥95%
• Synonyms: 1-[5-Hydroxy-2-[2-hydroxy-3-(propylamino)propoxy]phenl]-3-phenyl-1-propanone Hydrochloride; GPV 129
• Solubility: DMSO (Slightly), Methanol (Slightly)
• Appearance: White to Light Yellow Solid
• Storage: -20°C
• IUPAC Name: 1-[5-hydroxy-2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one;hydrochloride
• InChI: InChI=1S/C21H27NO4.ClH/c1-2-12-22-14-18(24)15-26-21-11-9-17(23)13-19(21)20(25)10-8-16-6-4-3-5-7-16;/h3-7,9,11,13,18,22-24H,2,8,10,12,14-15H2,1H3;1H
• InChIKey: FAYLNKVZLXBDBE-UHFFFAOYSA-N
• SMILES: CCCNCC(COC1=C(C=C(C=C1)O)C(=O)CCC2=CC=CC=C2)O.Cl

5-Hydroxy propafenone hydrochloride (Cat No.:C000794) is a chemical compound derived from propafenone, a class Ic antiarrhythmic medication used to treat certain heart rhythm disorders. The addition of a hydroxyl group at position 5 introduces a modified structure with potential alterations in pharmacological properties. Researchers likely explore this compound for its effects on cardiac ion channels, rhythm stabilization, and arrhythmia management. Investigations into its electrophysiological effects could lead to insights into its antiarrhythmic mechanisms and potential benefits in clinical settings.

Reference

Hege, H.G., et al.: Eur. J. Drug Metab. Pharmacokinet., 9, 41 (1984),